Known Issues/P0300/GMC

P0300 on GMC

Random/Multiple Cylinder Misfire Detected

Critical10 GMC models affected$200-$8,000 typical repairSystem: Engine
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P0300 on GMC vehicles indicates random/multiple cylinder misfire detected. Au7o has documented this code across 10 GMC models — most commonly on C/K 1500, Canyon, Safari. P0300 means the engine computer detected misfires occurring randomly or across multiple cylinders rather than in one specific cylinder. A misfire is when a cylinder fails to ignite its fuel-air mixture properly, which the computer senses through small fluctuations in crankshaft speed. Because it's not isolated to one cylinder, the cause is usually something that affects the whole engine — like fuel, air, or ignition system problems — rather than a single coil or plug. Persistent or heavy misfiring wastes fuel, runs rough, and can damage the catalytic converter, which is why a flashing check engine light should be taken seriously. Typical repair costs on GMC range from $200 to $8,000, depending on the specific model and root cause.

Common Causes of P0300

  • •Worn or fouled spark plugs (across cylinders)
  • •Vacuum or intake air leak
  • •Weak fuel pump, clogged fuel filter, or low fuel pressure
  • •Failing ignition coils or worn spark plug wires
  • •Dirty or faulty mass airflow (MAF) sensor
  • •Clogged or dirty fuel injectors
  • •Faulty crankshaft/camshaft position sensor
  • •Low compression or EGR/PCV system faults

P0300 on GMC by Model

GMC C/K 1500(1 issue)

  • 5.7L Vortec Spider Injector Assembly Failure1996-1998

    Same CPI spider injector issue as Chevrolet C/K. The 5.7L Vortec V8 spider assembly poppet nozzles clog and fuel lines crack.

GMC Canyon(1 issue)

  • Active Fuel Management (AFM) Lifter Failure (V6)2015-2025

    The 3.6L V6 with Active Fuel Management experiences lifter failure where the AFM lifters collapse, causing misfires and a ticking noise. The collapsing lifter can damage the camshaft lobe if not addressed.

GMC Safari(1 issue)

  • 4.3L Central Port Injection (CPI) Spider Injector Failure1996-2005

    The 4.3L Vortec in the Safari uses a central port injection system ('spider injector') that develops poppet valve sticking and fuel line cracks. This causes hard starting, rough idle, and a strong fuel smell from leaking fuel inside the intake manifold.

GMC Savana(1 issue)

  • AFM Lifter Failure on V8 Vortec/EcoTec3 Engines2010-2025

    GMC Savana vans equipped with 4.8L (L20), 5.3L (LM7), and 6.0L (L96) V8 engines with Active Fuel Management suffer the same AFM lifter collapse problem documented across the entire GM full-size truck/van lineup. The collapsible AFM lifters on deactivation cylinders fail between 60,000-120,000 miles, causing misfires, engine ticking, rough idle, and potential engine damage. Commercial Savana vans used for fleet operations are especially vulnerable due to high mileage accumulation and variable maintenance practices. The problem affects all GMT600 platform Savana/Express vans with AFM-equipped engines.

GMC Sierra 1500(2 issues)

  • AFM/DFM Lifter Collapse and Failure2014-2023

    The Active Fuel Management (AFM) and Dynamic Fuel Management (DFM) systems use special hydraulic lifters that collapse to deactivate cylinders for fuel economy. These lifters are prone to premature failure due to poor physical design and inadequate oil flow. Failures can occur as early as 4-digit mileage on newer trucks or 50,000-100,000 miles on older models. When a lifter fails, it can cause catastrophic engine damage requiring complete engine teardown.

  • Direct Injection Carbon Buildup on Intake Valves2014-2023

    Direct injection engines do not spray fuel over the intake valves like port injection systems, allowing carbon deposits from oil and blow-by gases via the PCV system to accumulate on intake valve backs and ports. Over time, this buildup restricts airflow causing performance and efficiency loss. The 5.3L and 6.2L engines with direct injection are susceptible to this issue typically after 60,000-100,000 miles.

GMC Sierra 2500HD(2 issues)

  • LML Duramax EGR Cooler and EGR Valve Failure2011-2016

    The LML Duramax EGR (exhaust gas recirculation) cooler is prone to coolant leaks internally, allowing coolant to enter the intake manifold and combustion chambers. Coolant in the intake causes white smoke, rough running, and potential hydrolocking of cylinders. The EGR valve also sticks open or closed from carbon buildup, causing rough idle, black smoke, and check engine lights. The EGR cooler failure can occur as early as 60,000 miles on trucks used in stop-and-go driving. GM issued multiple TSBs addressing EGR cooler design improvements.

  • 6.0L V8 Excessive Oil Consumption and AFM Lifter Wear2014-2020

    The 6.0L L96 V8 gasoline engine in Sierra 2500HD (non-diesel) suffers from Active Fuel Management (AFM) lifter failures similar to the 5.3L in Sierra 1500 — though less frequently due to the higher displacement. More commonly, 6.0L engines exhibit excessive oil consumption (1 qt per 1,000-3,000 miles) from worn valve stem seals and piston rings, particularly between 100,000-150,000 miles. The L96 is a high-output truck engine subjected to heavy towing and payload, which accelerates wear on AFM components.

GMC Suburban(1 issue)

  • 5.7L Vortec Intake Manifold Gasket and CPI Issues1996-1999

    The GMC Suburban shares the same 5.7L Vortec intake gasket and spider injector issues as the C/K 1500. The larger vehicle runs hotter, which can accelerate gasket degradation.

GMC Terrain(1 issue)

  • Ecotec 2.4L Timing Chain and Tensioner Failure2010-2014

    The GM Ecotec 2.4L in the 2010-2014 Terrain has the same timing chain stretch and tensioner failure as the Equinox and Malibu. GM Special Coverage Adjustment SCA 12313C covers some vehicles. The 2010-2011 models are worst affected. Improperly hardened piston rings on 2010-2013 models cause excessive oil burning, which leads to low oil and accelerated timing chain wear. 2015+ models received revised internal components.

GMC Yukon(1 issue)

  • AFM/DOD Lifter Collapse and Valvetrain Failure2007-2020

    The GMC Yukon 5.3L (L83, LC9, LMG) and 6.2L (L94, L86) V8 engines use Active Fuel Management (AFM) cylinder deactivation. The special collapsible AFM lifters on cylinders 1, 4, 6, and 7 fail prematurely, causing misfires, engine ticking, rough idle, and potential catastrophic damage. This is the single most reported mechanical failure on GMT900 (2007-2014) and K2XX (2015-2020) Yukon models. GM issued TSB 18-NA-077 acknowledging the issue. Yukon models used as daily drivers with lots of highway cruising (where AFM activates most) are most susceptible. The VLOM (Valve Lifter Oil Manifold) must also be replaced as it controls oil flow to AFM lifters.

GMC Yukon XL(1 issue)

  • Active Fuel Management (AFM) Lifter Failure and Tick2007-2019

    The Yukon XL with the 5.3L or 6.2L V8 and Active Fuel Management (AFM/DOD) system develops hydraulic valve lifter failures. The AFM lifters, which collapse to deactivate cylinders for fuel economy, fail and cause persistent ticking noise, misfires, and potential camshaft damage. The problem is most common on 2007-2019 models. GM service bulletin recommends replacing all 8 AFM lifters if ticking persists after oil change.

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Frequently Asked Questions

What does P0300 mean on GMC?▼

P0300 stands for "Random/Multiple Cylinder Misfire Detected." P0300 means the engine computer detected misfires occurring randomly or across multiple cylinders rather than in one specific cylinder. A misfire is when a cylinder fails to ignite its fuel-air mixture properly, which the computer senses through small fluctuations in crankshaft speed. Because it's not isolated to one cylinder, the cause is usually something that affects the whole engine — like fuel, air, or ignition system problems — rather than a single coil or plug. Persistent or heavy misfiring wastes fuel, runs rough, and can damage the catalytic converter, which is why a flashing check engine light should be taken seriously. On GMC specifically, this code is documented across 10 models.

What causes P0300 on GMC vehicles?▼

Common causes on GMC: Worn or fouled spark plugs (across cylinders), Vacuum or intake air leak, Weak fuel pump, clogged fuel filter, or low fuel pressure, Failing ignition coils or worn spark plug wires, Dirty or faulty mass airflow (MAF) sensor. Specific causes vary by model and year — see the per-model sections below.

How much does it cost to fix P0300 on a GMC?▼

Repair costs on GMC range from $200 to $8,000, depending on the specific model and root cause.

Which GMC models have P0300 documented?▼

Au7o has documented P0300 on 10 GMC models: C/K 1500, Canyon, Safari, Savana, Sierra 1500, Sierra 2500HD, Suburban, Terrain, Yukon, Yukon XL.

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