Known Issues/P0301/RAM

P0301 on RAM

Cylinder 1 Misfire Detected

Moderate3 RAM models affected$200-$5,500 typical repairSystem: Engine
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P0301 on RAM vehicles indicates cylinder 1 misfire detected. Au7o has documented this code across 3 RAM models — most commonly on 1500, 1500 Classic, 3500. P0301 means the engine computer detected a misfire specifically in cylinder 1 — the spark didn't ignite the fuel properly, or the fuel/air mix didn't burn as it should. The computer detects this by sensing tiny variations in crankshaft speed each time a cylinder fires. A misfire wastes fuel, raises emissions, and can damage the catalytic converter if it's severe or persistent (a flashing check engine light usually warns of active, converter-damaging misfires). Because the code points to one specific cylinder, the cause is usually an ignition, fuel, or compression problem isolated to that cylinder. Typical repair costs on RAM range from $200 to $5,500, depending on the specific model and root cause.

Common Causes of P0301

  • •Worn or fouled spark plug in cylinder 1
  • •Failed ignition coil or coil pack for cylinder 1
  • •Faulty or clogged fuel injector for cylinder 1
  • •Vacuum or intake air leak affecting that cylinder
  • •Bad spark plug wire (on applicable engines)
  • •Low compression (worn rings, leaking or burnt valve, head gasket)
  • •Carbon buildup on intake valves
  • •Wiring or connector fault to the coil or injector

P0301 on RAM by Model

RAM 1500(1 issue)

  • HEMI Lifter/Camshaft Failure2009-2019

    The 5.7L HEMI engine with Multi-Displacement System (MDS) can experience premature lifter and camshaft wear. The MDS deactivation lifters are prone to failure, causing ticking, misfires, and in severe cases, camshaft lobe damage. This issue has led to class action lawsuits.

RAM 1500 Classic(2 issues)

  • 5.7L HEMI MDS Lifter Failure2019-2024

    The 5.7L HEMI with Multi-Displacement System (MDS) in the 1500 Classic develops lifter failure, particularly on cylinders that deactivate. The roller lifters can collapse or seize, causing ticking noise and misfires. This is the same issue as the standard 1500.

  • MDS Lifter Failure and Hemi Tick (5.7L)2019-2025

    The 5.7L Hemi V8 uses Multi-Displacement System (MDS) hydraulic lifters to deactivate four cylinders during light-load cruising. The MDS lifters are known to fail, causing a persistent ticking noise (the infamous "Hemi tick") and misfires on the deactivated cylinders. When an MDS lifter collapses or sticks, it cannot properly deactivate and reactivate the valve, leading to a dead cylinder. In severe cases, a failed lifter can damage the camshaft lobe, requiring a complete top-end rebuild.

RAM 3500(1 issue)

  • 6.7L Cummins Exhaust Brake Actuator and VGT Turbo Issues2013-2025

    The RAM 3500 6.7L Cummins equipped with the integrated exhaust brake system experiences failures of the VGT (Variable Geometry Turbocharger) actuator and exhaust brake solenoid. The exhaust brake uses the VGT turbo vanes to create backpressure for engine braking while towing. The electronic actuator (Holset HE351VE/HE300VG) sticks or fails due to carbon buildup, causing loss of exhaust brake function, reduced turbo performance, limp mode, and DTC codes P2263 or P006A. TSB 14-001-21 addresses VGT actuator calibration. Actuator replacement costs $800-1,500; complete turbo replacement is $2,500-4,000.

Looking for P0301 on a different make?

View P0301 across all makes →

Frequently Asked Questions

What does P0301 mean on RAM?▼

P0301 stands for "Cylinder 1 Misfire Detected." P0301 means the engine computer detected a misfire specifically in cylinder 1 — the spark didn't ignite the fuel properly, or the fuel/air mix didn't burn as it should. The computer detects this by sensing tiny variations in crankshaft speed each time a cylinder fires. A misfire wastes fuel, raises emissions, and can damage the catalytic converter if it's severe or persistent (a flashing check engine light usually warns of active, converter-damaging misfires). Because the code points to one specific cylinder, the cause is usually an ignition, fuel, or compression problem isolated to that cylinder. On RAM specifically, this code is documented across 3 models.

What causes P0301 on RAM vehicles?▼

Common causes on RAM: Worn or fouled spark plug in cylinder 1, Failed ignition coil or coil pack for cylinder 1, Faulty or clogged fuel injector for cylinder 1, Vacuum or intake air leak affecting that cylinder, Bad spark plug wire (on applicable engines). Specific causes vary by model and year — see the per-model sections below.

How much does it cost to fix P0301 on a RAM?▼

Repair costs on RAM range from $200 to $5,500, depending on the specific model and root cause.

Which RAM models have P0301 documented?▼

Au7o has documented P0301 on 3 RAM models: 1500, 1500 Classic, 3500.

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